Vitamin D3 Supplementation at 4000 International Units Per Day for One Year Results in a Decrease of Positive Cores at Repeat Biopsy in Subjects with Low-Risk Prostate Cancer under Active Surveillance

• Published in: The journal of clinical endocrinology and metabolism Vol. 97; no. 7; pp. 2315 - 2324
• Main Authors: Marshall, David T., Savage, Stephen J., Garrett-Mayer, Elizabeth, Keane, Thomas E., Hollis, Bruce W., Horst, Ronald L., Ambrose, Linda H., Kindy, Mark S., Gattoni-Celli, Sebastiano
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.07.2012; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adverse events; Aged; Biological and medical sciences; Biopsy; Biopsy, Fine-Needle; Carcinoma - diet therapy; Carcinoma - etiology; Carcinoma - pathology; Carcinoma - prevention & control; Cholecalciferol - administration & dosage; Cholecalciferol - pharmacology; Dietary Supplements; Dose-Response Relationship, Drug; Down-Regulation; Drug development; Endocrine Care; Endocrinopathies; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Humans; International System of Units; Male; Medical sciences; Middle Aged; Patients; Population Surveillance; Prostate - pathology; Prostate cancer; Prostate-specific antigen; Prostatic Neoplasms - diet therapy; Prostatic Neoplasms - etiology; Prostatic Neoplasms - pathology; Prostatic Neoplasms - prevention & control; Risk Factors; Serum levels; Surveillance; Time Factors; Treatment Outcome; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Vitamin D; Vitamin D3; Watchful Waiting - methods; World; Human; Obesity; Urinary system disease; Prostate disease; Nutrition; Nutrition disorder; Metabolic diseases; Malignant tumor; Low risk; Result; Surveillance; Vitamin D; Biopsy; Supplementation; Male genital diseases; Prostate cancer; Endocrinology; Nutritional status; Cancer; Colecalciferol; International

Context:We wanted to investigate vitamin D in low-risk prostate cancer.Objectives:The objective of the study was to determine whether vitamin D3 supplementation at 4000 IU/d for 1 yr is safe and would result in a decrease in serum levels of prostate-specific antigen (PSA) or in the rate of progressi...