Survival and safety after neoadjuvant chemotherapy or upfront surgery for locally advanced colon cancer: meta-analysis

• Published in: British journal of surgery Vol. 111; no. 2
• Main Authors: Aliseda, Daniel, Arredondo, Jorge, Sánchez-Justicia, Carlos, Alvarellos, Alicia, Rodríguez, Javier, Matos, Ignacio, Rotellar, Fernando, Baixauli, Jorge, Pastor, Carlos
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 31.01.2024
• Subjects: Chemotherapy, Adjuvant; Colectomy; Colonic Neoplasms - drug therapy; Colonic Neoplasms - mortality; Colonic Neoplasms - pathology; Colonic Neoplasms - surgery; Disease-Free Survival; Humans; Neoadjuvant Therapy; Survival Rate; Systematic Review

Abstract Background Neoadjuvant chemotherapy is increasingly used to treat locally advanced (T3–4 Nx–2 M0) colon cancer due to its potential advantages over the standard approach of upfront surgery. The primary objective of this systematic review and meta-analysis was to analyse data from comparativ...