Vitamin D Deficiency Exacerbates Experimental Stroke Injury and Dysregulates Ischemia-Induced Inflammation in Adult Rats

• Published in: Endocrinology (Philadelphia) Vol. 153; no. 5; pp. 2420 - 2435
• Main Authors: Balden, Robyn, Selvamani, Amutha, Sohrabji, Farida
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.05.2012; Endocrine Society
• Subjects: Animals; Brain Ischemia - complications; Brain Ischemia - metabolism; Brain Ischemia - pathology; Calciferol; Cardiovascular diseases; Cerebral blood flow; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; Corpus Striatum - metabolism; Corpus Striatum - pathology; Cytokines - metabolism; Diet; Dietary supplements; Female; Inflammation; Inflammation - complications; Inflammation - metabolism; Inflammation - pathology; Inflammatory response; Insulin-like growth factor I; Insulin-Like Growth Factor I - metabolism; Interleukins; Ischemia; Neostriatum; Neuroendocrinology; Neuroprotection; Occlusion; Rats; Rats, Sprague-Dawley; Risk factors; Sensorimotor system; Stroke; Stroke - complications; Stroke - metabolism; Stroke - pathology; Vitamin D; Vitamin D Deficiency - complications; Vitamin D Deficiency - metabolism; Vitamin D Deficiency - pathology; Vitamin deficiency; γ-Interferon

Vitamin D deficiency (VDD) is widespread and considered a risk factor for cardiovascular disease and stroke. Low vitamin D levels are predictive for stroke and more fatal strokes in humans, whereas vitamin D supplements are associated with decreased risk of all-cause mortality. Because VDD occurs wi...