miR-664 negatively regulates PLP2 and promotes cell proliferation and invasion in T-cell acute lymphoblastic leukaemia

• Published in: Biochemical and biophysical research communications Vol. 459; no. 2; pp. 340 - 345
• Main Authors: Zhu, Hong, Miao, Mei-Hua, Ji, Xue-Qiang, Xue, Jun, Shao, Xue-Jun
• Format: Journal Article
• Language: English
• Published: United States 03.04.2015
• Subjects: 60 APPLIED LIFE SCIENCES; Cell Line, Tumor; Cell Movement - genetics; CELL PROLIFERATION; Cell Proliferation - genetics; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; GENES; Humans; Jurkat Cells; LEUKEMIA; LUCIFERASE; MARVEL Domain-Containing Proteins - genetics; MicroRNAs - antagonists & inhibitors; MicroRNAs - genetics; MIGRATION; Neoplasm Invasiveness - genetics; Neoplasm Invasiveness - pathology; PATHOGENESIS; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - therapy; Proteolipids - genetics; RNA, Neoplasm - antagonists & inhibitors; RNA, Neoplasm - genetics; miR-664; T-ALL; PLP2

MicroRNAs (miRNAs) play important roles in the pathogenesis of many types of cancers by negatively regulating gene expression at posttranscriptional level. However, the role of microRNAs in leukaemia, particularly T-cell acute lymphoblastic leukaemia (T-ALL), has remained elusive. Here, we identifie...