Diabetes Induces p66shc Gene Expression in Human Peripheral Blood Mononuclear Cells: Relationship to Oxidative Stress

• Published in: The journal of clinical endocrinology and metabolism Vol. 90; no. 2; pp. 1130 - 1136
• Main Authors: Pagnin, Elisa, Fadini, Gianpaolo, de Toni, Renzo, Tiengo, Antonio, Calò, Lorenzo, Avogaro, Angelo
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.02.2005; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adaptor Proteins, Signal Transducing - deficiency; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - physiology; Animals; Biological and medical sciences; Cardiovascular diseases; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus - genetics; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Dinoprost - analogs & derivatives; Dinoprost - blood; Disease resistance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation; Humans; Leukocytes (mononuclear); Leukocytes, Mononuclear - physiology; Life span; Lymphocytes; Medical sciences; Mice; Mice, Knockout; Middle Aged; Monocytes; Oxidative stress; Oxidative Stress - physiology; Peripheral blood mononuclear cells; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - blood; RNA, Messenger - genetics; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Vertebrates: endocrinology; Endocrinopathy; Human; Oxidative stress; Blood cell; Mononuclear cell; Diabetes mellitus; Gene expression; Endocrinology

Oxidative stress plays a role in cardiovascular dysfunction. This is of interest in diabetes, a clinical condition characterized by oxidative stress and increased prevalence of cardiovascular disease. The role of p66shc in oxidative stress-related response has been demonstrated by resistance to and...