Low functional programming of renal AT{sub 2}R mediates the developmental origin of glomerulosclerosis in adult offspring induced by prenatal caffeine exposure

• Published in: Toxicology and applied pharmacology Vol. 287; no. 2
• Main Authors: Ao, Ying, Hubei Provincial Key Laboratory of Developmentally Originated Disorder, Wuhan 430071, Sun, Zhaoxia, Hu, Shuangshuang, Zuo, Na, Li, Bin, Yang, Shuailong, Xia, Liping, Wu, Yong, Wang, Linlong, He, Zheng, Wang, Hui
• Format: Journal Article
• Language: English
• Published: United States 01.09.2015
• Subjects: 60 APPLIED LIFE SCIENCES; ADULTS; ANGIOTENSIN; CAFFEINE; CREATININE; FETUSES; FIBROSIS; GENES; HAZARDS; KIDNEYS; MICROSCOPES; PLANT GROWTH; PROGENY; PROGRAMMING; RATS; RECEPTORS; SIGNALS; TYROSINE; URINE

Our previous study has indicated that prenatal caffeine exposure (PCE) could induce intrauterine growth retardation (IUGR) of offspring. Recent research suggested that IUGR is a risk factor for glomerulosclerosis. However, whether PCE could induce glomerulosclerosis and its underlying mechanisms rem...