돌연변이 p53 단백질의 Silencing에 의한 사람유방암세포의 in vivo 항종양 효과

• Published in: KSBB Journal Vol. 31; no. 1; pp. 52 - 57
• Main Authors: 박원익(Won Ick Park), 박세라(Se-Ra Park), 박현주(Hyun-Joo Park), 배윤희(Yun-Hee Bae), 유현수(Hyun Su Ryu), 장혜옥(Hye-Ock Jang), 배문경(Moon-Kyoung Bae), 배수경(Soo-Kyung Bae)
• Format: Journal Article
• Language: Korean
• Published: 한국생물공학회 01.03.2016
• Subjects: 생물공학; Breast cancer; Xenograft tumor model; Mutant p53; Apoptosis

Mutant p53 (R280K) is highly expressed in MDAMB- 231 triple-negative human breast cancer cells. Currently, we reported the role of mutant p53-R280K in mediating the survival of MDA-MB-231 cells in vitro. The present study was undertaken to determine whether mutant p53-R280K affects breast cancer cel...