인체 위암세포주에서 半枝蓮의 항암 효능에 관한 연구

The aim of the study is to investigate the anti-cancer effects of Scutellaria barbata in AGS human gastric adenocarcinoma cells. MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay and caspase 3 or 9 activity assay were carried out to examine cell death with Scutellaria barbat...

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Published in동의생리병리학회지 Vol. 29; no. 2; pp. 195 - 201
Main Authors 심지환(Ji Hwan Shim), 이수진(Soojin Lee), 김희진(Huijin Gim), 박현수(Hyun Soo Park), 김병주(Byung Joo Kim)
Format Journal Article
LanguageKorean
Published 한의병리학회 01.04.2015
Subjects
한의학
Cutellaria barbata
Human gastric adenocarcinoma cancer cell
AGS
Anti-cancer drugs
Online AccessGet full text
ISSN1738-7698
2288-2529
DOI10.15188/kjopp.2015.04.29.2.195

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Abstract The aim of the study is to investigate the anti-cancer effects of Scutellaria barbata in AGS human gastric adenocarcinoma cells. MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay and caspase 3 or 9 activity assay were carried out to examine cell death with Scutellaria barbata. To elucidate the inhibitory effects of Scutellaria barbata, cell cycle (sub-G1) analysis and mitochondrial membrane potential were performed in AGS cells after 24 h incubation with Scutellaria barbata. Scutellaria barbata induced apoptosis in AGS cells by using the MTT assay, the sub-G1 analysis and mitochondrial membrane potential assay. The stronger inhibition effects of AGS cell growth was observed by application of Scutellaria barbata combined with several anti-cancer drugs (paclitaxel, 5-fluorouracil, cisplatin, ectoposide, doxorubicin and docetaxel) in comparison to the application of Scutellaria barbata or anti-cancer drugs. Our findings provide insight into unraveling the effects of Scutellaria barbata in human gastric cancer cells and developing therapeutic agents against gastric cancer. KCI Citation Count: 1
AbstractList The aim of the study is to investigate the anti-cancer effects of Scutellaria barbata in AGS human gastric adenocarcinoma cells. MTT (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay and caspase 3 or 9 activity assay were carried out to examine cell death with Scutellaria barbata. To elucidate the inhibitory effects of Scutellaria barbata, cell cycle (sub-G1) analysis and mitochondrial membrane potential were performed in AGS cells after 24 h incubation with Scutellaria barbata. Scutellaria barbata induced apoptosis in AGS cells by using the MTT assay, the sub-G1 analysis and mitochondrial membrane potential assay. The stronger inhibition effects of AGS cell growth was observed by application of Scutellaria barbata combined with several anti-cancer drugs (paclitaxel, 5-fluorouracil, cisplatin, ectoposide, doxorubicin and docetaxel) in comparison to the application of Scutellaria barbata or anti-cancer drugs. Our findings provide insight into unraveling the effects of Scutellaria barbata in human gastric cancer cells and developing therapeutic agents against gastric cancer. KCI Citation Count: 1
Author 이수진(Soojin Lee)
박현수(Hyun Soo Park)
김병주(Byung Joo Kim)
심지환(Ji Hwan Shim)
김희진(Huijin Gim)
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Human gastric adenocarcinoma cancer cell
AGS
Anti-cancer drugs
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Title 인체 위암세포주에서 半枝蓮의 항암 효능에 관한 연구
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