담낭암 환자에서 Gemcitabine을 기본으로 한 보조 항암화학요법의 경험

• Published in: Annals of surgical treatment and research Vol. 75; no. 4; pp. 255 - 261
• Main Authors: 이승원(Seung Won Lee), 김형철(Hyung Chul Kim), 주종우(Chong Woo Chu), 정준철(Jun Chul Chung), 정귀애(Gui Ae Chung)
• Format: Journal Article
• Language: Korean
• Published: 대한외과학회 01.10.2008
• Subjects: 일반외과학; 보조 항암화학요법; Chemotherapy; 젬시타빈; Gemcitabine; Gallbladder cancer; 담낭암
• ISSN: 2288-6575; 2288-6796

Purpose: Patients with gallbladder cancer tend to have advanced, unresectable tumor at the time of presentation and they face a dismal prognosis in the absence of a standard chemotherapy regimen. This study was performed to evaluate the outcomes of patients with gallbladder cancer and who underwent postoperative gemcitabine-based chemotherapy. Methods: From March of 2001 to February of 2008, a total of 27 patients underwent operation for gallbladder cancer. They underwent two types of gemcitabine-based chemotherapy. One type of regimen was the combined administration of gemcitabine 1,000 mg/m2 and 5-fluorouracil 200 mg/m2. The other one was combined administration of gemcitabine 1,000 mg/m2 and cisplatin 70 mg/m2. Results: Among the 27 patients, 15 patients were treated with gemcitabine-based chemotherapy and 12 patients were treated with many kinds of the best supportive care without chemotherapy. The median survival was 29.1±2.7 months and 15.7±2.8 months, respectively. The median survival and disease free survival for the gemcitabine based chemotherapy group who received curative resection was 31.6±2.5 and 15.7±3.2 months, respectively. The median survival and disease free survival for the patients without chemotherapy after curative resection was 16.3±2.9 and 15.7±3.2 months, respectively. Conclusion: Patients with gallbladder cancer and who received adjuvant gemcitabine-based chemotherapy had a relatively favorable prognosis. Especially, gemcitabine-based combination chemotherapy could be effective and acceptable for the treatment of gallbladder cancer patients who have undergone curative resection. (J Korean Surg Soc 2008;75:255-261) KCI Citation Count: 2