마취 유도제로 사용한 Propofol과 예방적으로 투여한 Metoclopramide의 술 후 오심 및 구토에 미치는 영향

• Published in: Korean journal of anesthesiology pp. 179 - 183
• Main Authors: 박현희, 박관식, 이숙영, 조외경, 김재형, 김진수, 신동욱
• Format: Journal Article
• Language: Korean
• Published: 대한마취통증의학회 01.02.2006
• Subjects: 마취과학
• ISSN: 2005-6419; 2005-7563

Background: Postoperative nausea and vomiting (PONV) are common problems in patients undergoing a laparoscopic cholecystectomy. This study evaluated the effect of prophylactic metoclopramide (MCP) and induction with propofol on PONV. Methods: 165 patients undergoing laparoscopic cholecystectomy were randomly divided into four groups. Groups 1 (control group) and 2 were inducted with thiopental sodium. Groups 3 (propofol group) and 4 were inducted with propofol. Prophylactic metoclopramide 10 mg i.v. was administered in Groups 2 (MCP group) and 4 (propofol + MCP group). The incidence of PONV, the need for rescue antiemetics, adverse events, and the nausea severity scores were assessed at 0 to 1 hour and at 1 to 24 hours postoperatively. Results: During the first 24 hours after anesthesia, the incidence of PONV in Groups 1, 2, 3 and 4 was 41.5%, 29.3%, 30.3% and 23.3%, respectively. There was no significant difference between the groups. During the period, 1 hour to 24 hours, after anesthesia, the incidence of PONV in Groups 1, 2, 3 and 4 was 36.6%, 17.4%, 27.5% and 14.4%, respectively. The incidence of PONV in Group 4 was significantly lower than in Group 1 (P ＜ 0.05). Conclusions: In patients with laparoscopic cholecystectomy, a combination of prophylactic metoclopramide administration and induction with propofol was found to reduce the incidence of PONV by about 22.6% during the period 1 hour to 24 hours after anesthesia. (Korean J Anesthesiol 2006; 50: 179～83) KCI Citation Count: 3