Overexpression of -aminobutyric acid transporter subtype I leads to susceptibility to kainic acid-induced seizure in transgenic mice

• Published in: Cell research Vol. 11; no. 1; pp. 61 - 67
• Main Authors: Ma, Ying Hua, Hu, Jia Hua, Zhao, Wen Juan, Fei, Jian, Yu, Yun, Zhou, Xiao Gang, Mei, Zhen Tong, Guo, Li He
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 01.03.2001

Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter, and the GABAergic synaptic transmission is normally terminated by the rapid uptake through GABA transporters. With transgenic mice ubiquitously overexpressing GABA transporter subtype I (GAT1), the present study explored th...