The exonuclease ISG20 is directly induced by synthetic dsRNA via NF- B and IRF1 activation

• Published in: Oncogene Vol. 23; no. 26; pp. 4636 - 4640
• Main Authors: Espert, Lucile, Rey, Clémence, Gonzalez, Laure, Degols, Geneviève, Chelbi-Alix, Mounira Kmar, Mechti, Nadir, Gongora, Céline
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group 03.06.2004
• Subjects: Hypotheses; Infections; Kinases; Proteins; Transcription factors; Viral infections; Viruses

Many interferon (IFN)-stimulated genes are also induced by double-stranded RNA (dsRNA), a component closely associated with the IFN system in the context of virus-host interactions. Recently, we demonstrated that the IFN-induced 3' --> 5' exonuclease ISG20 possesses antiviral activities...