Association of haplotypes in the -chemokine locus with multiple sclerosis

• Published in: European journal of human genetics : EJHG Vol. 13; no. 2; pp. 240 - 247
• Main Authors: Vyshkina, Tamara, Yin Yao Shugart, Birnbaum, Gary, Leist, Thomas P, Kalman, Bernadette
• Format: Journal Article
• Language: English
• Published: Leiden Nature Publishing Group 01.02.2005
• Subjects: Alleles; Antagonists; CCL3 protein; Cell cycle; Chemokines; Children; Chromosome 17; Data processing; Deoxyribonucleic acid; Disease; DNA; Epidemiology; Genes; Genetics; Genomes; Haplotypes; Ligands; Linkage disequilibrium; Monocyte chemoattractant protein 1; Multiple sclerosis; Neurology; Patients; Sclerosis; New York; United States > US; San Francisco California

Linkage studies in multiple sclerosis (MS) identified several susceptibility loci. One of these regions includes chromosome 17q11 where a meta-analysis of data from three genome scans suggested linkage. This region encodes a cluster of genes for beta-chemokines or CC chemokine ligands (CCLs), which...