Cigarette smoke-exposed neutrophils die unconventionally but are rapidly phagocytosed by macrophages

• Published in: Cell death & disease Vol. 2; no. 3; p. e131
• Main Authors: Guzik, K, Skret, J, Smagur, J, Bzowska, M, Gajkowska, B, Scott, D A, Potempa, J S
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2011; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/250/2504/223/1699; 631/80/313/1727; 631/80/82; 692/698/690/292; Antibodies; Apoptosis; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cells, Cultured; Humans; Immunology; Life Sciences; Macrophages - immunology; Neutrophils - cytology; Neutrophils - immunology; Original; original-article; Phagocytosis; Pulmonary Disease, Chronic Obstructive - genetics; Pulmonary Disease, Chronic Obstructive - immunology; Pulmonary Disease, Chronic Obstructive - physiopathology; Scavenger Receptors, Class A - genetics; Scavenger Receptors, Class A - immunology; Scavenger Receptors, Class E - genetics; Scavenger Receptors, Class E - immunology; Smoking - adverse effects; Smoking - genetics; Smoking - immunology; Smoking - physiopathology; Staphylococcus aureus; phagocytosis; tobacco smoke; cell death; monocytes/macrophages; neutrophils; scavenger receptors

Pulmonary accumulation of neutrophils is typical for active smokers who are also predisposed to multiple inflammatory and infectious lung diseases. We show that human neutrophil exposure to cigarette smoke extract (CSE) leads to an atypical cell death sharing features of apoptosis, autophagy and nec...