Sex-dependent regulation of vertebrate somatic growth and aging by germ cells

The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in vertebrates. We demonstrated sex-dependent somatic regulation by germ cells in the short-lived vertebrate model . In females, germ cell removal shortened life span, decreased es...

Full description

Saved in:
Bibliographic Details
Published inScience advances Vol. 10; no. 24; p. eadi1621
Main Authors Abe, Kota, Ino, Hikaru, Niwa, Tomomi, Semmy, Daniel, Takaochi, Ayami, Nishimura, Takashi, Mogi, Chihiro, Uenaka, Maki, Ishii, Masaru, Tanaka, Kaori, Ohkawa, Yasuyuki, Ishitani, Tohru
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 14.06.2024
Subjects
Aging - physiology
Animals
Biomedicine and Life Sciences
Body Size
Developmental Biology
Estrogens - metabolism
Female
Germ Cells - cytology
Germ Cells - metabolism
Insulin-Like Growth Factor I - metabolism
Male
SciAdv r-articles
Sex Characteristics
Signal Transduction
Vertebrates
Vitamin D - metabolism
Online AccessGet full text

Cover

Abstract The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in vertebrates. We demonstrated sex-dependent somatic regulation by germ cells in the short-lived vertebrate model . In females, germ cell removal shortened life span, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling. In contrast, germ cell removal in males improved their health with increased vitamin D signaling. Body size increased in both sexes but was caused by different signaling pathways, i.e., IGF-1 and vitamin D in females and males, respectively. Thus, vertebrate germ cells regulate somatic growth and aging through different pathways of the endocrine system, depending on the sex, which may underlie the sexual difference in reproductive strategies.
AbstractList The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in vertebrates. We demonstrated sex-dependent somatic regulation by germ cells in the short-lived vertebrate model Nothobranchius furzeri. In females, germ cell removal shortened life span, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling. In contrast, germ cell removal in males improved their health with increased vitamin D signaling. Body size increased in both sexes but was caused by different signaling pathways, i.e., IGF-1 and vitamin D in females and males, respectively. Thus, vertebrate germ cells regulate somatic growth and aging through different pathways of the endocrine system, depending on the sex, which may underlie the sexual difference in reproductive strategies.The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in vertebrates. We demonstrated sex-dependent somatic regulation by germ cells in the short-lived vertebrate model Nothobranchius furzeri. In females, germ cell removal shortened life span, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling. In contrast, germ cell removal in males improved their health with increased vitamin D signaling. Body size increased in both sexes but was caused by different signaling pathways, i.e., IGF-1 and vitamin D in females and males, respectively. Thus, vertebrate germ cells regulate somatic growth and aging through different pathways of the endocrine system, depending on the sex, which may underlie the sexual difference in reproductive strategies.
The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in vertebrates. We demonstrated sex-dependent somatic regulation by germ cells in the short-lived vertebrate model Nothobranchius furzeri . In females, germ cell removal shortened life span, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling. In contrast, germ cell removal in males improved their health with increased vitamin D signaling. Body size increased in both sexes but was caused by different signaling pathways, i.e., IGF-1 and vitamin D in females and males, respectively. Thus, vertebrate germ cells regulate somatic growth and aging through different pathways of the endocrine system, depending on the sex, which may underlie the sexual difference in reproductive strategies. Germ cell removal affects the life span and body size of vertebrates in a sex-dependent manner.
The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in vertebrates. We demonstrated sex-dependent somatic regulation by germ cells in the short-lived vertebrate model . In females, germ cell removal shortened life span, decreased estrogen, and increased insulin-like growth factor 1 (IGF-1) signaling. In contrast, germ cell removal in males improved their health with increased vitamin D signaling. Body size increased in both sexes but was caused by different signaling pathways, i.e., IGF-1 and vitamin D in females and males, respectively. Thus, vertebrate germ cells regulate somatic growth and aging through different pathways of the endocrine system, depending on the sex, which may underlie the sexual difference in reproductive strategies.
Author Niwa, Tomomi
Semmy, Daniel
Ohkawa, Yasuyuki
Uenaka, Maki
Takaochi, Ayami
Mogi, Chihiro
Ishii, Masaru
Tanaka, Kaori
Ishitani, Tohru
Ino, Hikaru
Abe, Kota
Nishimura, Takashi
Author_xml – sequence: 1
  givenname: Kota
  orcidid: 0009-0003-5835-5867
  surname: Abe
  fullname: Abe, Kota
  organization: Department of Homeostatic Regulation, Division of Cellular and Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
– sequence: 2
  givenname: Hikaru
  surname: Ino
  fullname: Ino, Hikaru
  organization: Department of Homeostatic Regulation, Division of Cellular and Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
– sequence: 3
  givenname: Tomomi
  surname: Niwa
  fullname: Niwa, Tomomi
  organization: Department of Homeostatic Regulation, Division of Cellular and Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
– sequence: 4
  givenname: Daniel
  surname: Semmy
  fullname: Semmy, Daniel
  organization: Department of Homeostatic Regulation, Division of Cellular and Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
– sequence: 5
  givenname: Ayami
  surname: Takaochi
  fullname: Takaochi, Ayami
  organization: Department of Homeostatic Regulation, Division of Cellular and Molecular Biology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
– sequence: 6
  givenname: Takashi
  orcidid: 0000-0002-6773-0302
  surname: Nishimura
  fullname: Nishimura, Takashi
  organization: Metabolic Regulation and Genetics, Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
– sequence: 7
  givenname: Chihiro
  orcidid: 0000-0003-4356-2567
  surname: Mogi
  fullname: Mogi, Chihiro
  organization: Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan
– sequence: 8
  givenname: Maki
  orcidid: 0000-0002-2204-0551
  surname: Uenaka
  fullname: Uenaka, Maki
  organization: Immunology Frontier Research Center, Osaka University, Suita, Japan
– sequence: 9
  givenname: Masaru
  orcidid: 0000-0002-4215-007X
  surname: Ishii
  fullname: Ishii, Masaru
  organization: Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan
– sequence: 10
  givenname: Kaori
  surname: Tanaka
  fullname: Tanaka, Kaori
  organization: Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
– sequence: 11
  givenname: Yasuyuki
  orcidid: 0000-0001-6440-9954
  surname: Ohkawa
  fullname: Ohkawa, Yasuyuki
  organization: Division of Transcriptomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
– sequence: 12
  givenname: Tohru
  orcidid: 0000-0002-6200-7043
  surname: Ishitani
  fullname: Ishitani, Tohru
  organization: Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38865462$$D View this record in MEDLINE/PubMed
BookMark eNpVkM1PwzAMxSMEYmPsyhHlyKWjbps0OSE08SUNcQDOVZq6XVCbjKQb7L-niIHGyZaf9XvPPiGH1lkk5AziGUDCL4M2qtrMVGWAJ3BAxkmasyhhmTjc60dkGsJbHMeQcc5AHpNRKgRnGU_G5PEZP6MKV2grtD312Kxb1RtnqavpBn2PpVc90uC6Yaxp491Hv6TKVlQ1xja03NIGfUc1tm04JUe1agNOd3VCXm9vXub30eLp7mF-vYhsIqCPICt5mucVl0mMOQMBQiopJIohlNQZ6DoGpnSS6bpEJkALBlorndcsraRMJ-Tqh7talx1WeojuVVusvOmU3xZOmeK_Ys2yaNymAAAuMsYHwsWO4N37GkNfdCZ836AsunUo0pjnEhjkYlg93zf7c_l9YvoFSoh4hw
ContentType Journal Article
Copyright Copyright © 2024 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). 2024 The Authors
Copyright_xml – notice: Copyright © 2024 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). 2024 The Authors
DBID CGR
CUY
CVF
ECM
EIF
NPM
7X8
5PM
DOI 10.1126/sciadv.adi1621
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
DocumentTitleAlternate Germ cells control vertebrate aging and growth
EISSN 2375-2548
ExternalDocumentID 38865462
Genre Journal Article
GrantInformation_xml – fundername: ;
– fundername: ;
  grantid: 21gm5010001h0005
– fundername: ;
  grantid: 21H05148
– fundername: ;
  grantid: 22002
– fundername: ;
  grantid: 21H05287
– fundername: ;
  grantid: 20H04922
– fundername: ;
  grantid: 22H02820
– fundername: ;
  grantid: 20K15701
GroupedDBID 53G
5VS
AAFWJ
ACGFS
ADAXU
ADBBV
ADPDF
AENVI
AFPKN
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BBORY
BCGUY
BCNDV
BKF
CGR
CUY
CVF
EBS
ECM
EIF
FRP
GROUPED_DOAJ
HYE
KQ8
M48
M~E
NPM
OK1
OVD
OVEED
RHF
RHI
RPM
TEORI
7X8
5PM
ID FETCH-LOGICAL-n281t-14b6377d6920e7518189a989e85469c41cf015ac24cfbe581c851ccac7f53d993
IEDL.DBID RPM
ISSN 2375-2548
IngestDate Tue Sep 17 21:29:17 EDT 2024
Sat Oct 26 04:53:42 EDT 2024
Tue Oct 29 09:19:41 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 24
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-n281t-14b6377d6920e7518189a989e85469c41cf015ac24cfbe581c851ccac7f53d993
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0003-4356-2567
0009-0003-5835-5867
0000-0001-6440-9954
0000-0002-4215-007X
0000-0002-6773-0302
0000-0002-6200-7043
0000-0002-2204-0551
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11168456/
PMID 38865462
PQID 3067915178
PQPubID 23479
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_11168456
proquest_miscellaneous_3067915178
pubmed_primary_38865462
PublicationCentury 2000
PublicationDate 2024-Jun-14
PublicationDateYYYYMMDD 2024-06-14
PublicationDate_xml – month: 06
  year: 2024
  text: 2024-Jun-14
  day: 14
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Science advances
PublicationTitleAlternate Sci Adv
PublicationYear 2024
Publisher American Association for the Advancement of Science
Publisher_xml – name: American Association for the Advancement of Science
SSID ssj0001466519
Score 2.3193307
Snippet The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in vertebrates. We demonstrated...
SourceID pubmedcentral
proquest
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage eadi1621
SubjectTerms Aging - physiology
Animals
Biomedicine and Life Sciences
Body Size
Developmental Biology
Estrogens - metabolism
Female
Germ Cells - cytology
Germ Cells - metabolism
Insulin-Like Growth Factor I - metabolism
Male
SciAdv r-articles
Sex Characteristics
Signal Transduction
Vertebrates
Vitamin D - metabolism
SummonAdditionalLinks – databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PS8MwFA4yQXYR58_5iwge9NBh0jRNDyIijiHoRQe7lSRNtoG0unay_fe-tJ1u6slzG0jfe0m_l7z3fQidU-nrwErlUd8EHrOJ9SCUiWeFYxMXVkpVFsg-8V6fPQyCwXf9U23A_M_UzulJ9Sevndn7_AYW_PVSA4xMPjoyGRPuesrXqSPlcmV8NdQvz1sY54BWat7G38OaaMMXwrX20L_A5s-ayaWfUHcLbdboEd9W7m6hNZNuo1a9PnN8UZNIX-6gx2cz8xYKtwWeVJLz4AScWew0mN2FcWFwnpWcrXgI6XgxwjJNcKlbhNUcD2HXxu5kP99F_e79y13Pq6UTvJQKUniEKe6HYcIjemXczQoRkYxEZAR8YKQZ0RZwgNSUaatMIIgG5AXO1KEN_AQwyx5qpFlqDhAOOONMOWL40LBQW0CU1BLJEw3m8rVqo7OFtWIITTcrmZpsmscuG4kAUYSijfYr68VvFYdGvLB1G4kVu3694GivV5-k41FJfw27MxeA-w7_P_QINSmAE1fyRdgxahSTqTkBcFGo0zJqPgEsQtMJ
  priority: 102
  providerName: Scholars Portal
Title Sex-dependent regulation of vertebrate somatic growth and aging by germ cells
URI https://www.ncbi.nlm.nih.gov/pubmed/38865462
https://www.proquest.com/docview/3067915178
https://pubmed.ncbi.nlm.nih.gov/PMC11168456
Volume 10
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PT8IwFG6Akxcj_sQfpCYe9DCwXdd1R0MkxARjoiTcSNu1QCKDwDD63_taNgPGk5ddtiXde6_r99r3vg-hGypDHVmpAhqaKGA2tQGEMgmscGziwkqpfIHsM-8N2NMwGlYQL3thfNG-VtNW9j5rZdOJr61czHS7rBNrv_Q7MD-5gJW_XUVViNCtHN3vrDDOAZcUDI1Fh4xMP1oynRJOnTZMKIRr4qF_wcrf1ZFby033AO0XOBE_bMZTRxWTHaJ6MRNX-Lagi747Qv1X8xmUWrY5Xm7E5cHceG6xU1t2R8O5wau5Z2fFY0i88wmWWYq9QhFWX3gM_2fs9vBXx2jQfXzr9IJCJCHIqCB5QJjiYRynPKH3xp2hEJHIRCRGwAcmmhFtYcWXmjJtlYkE0YCxwG06tlGYAjo5QbVsnpkzhCPOOFOOAj42LNYWsCO1RPJUg7lCrRrourTWCILQjUpmZr5ejVzekQB2iEUDnW6sN1ps2DJGpa0bSOzY9ecBR3C9ewf87omuSz-f___VC7RHAYa44i7CLlEtX67NFcCIXDV9-g3XPhNNH0HffB_MsA
link.rule.ids 230,315,730,783,787,867,888,2228,24332,27938,27939,53806,53808
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9wwEB3BcoBLW77aLYUaiQMcksWO4zjHCoGWwiIkQHCLbMdeVi1ZtJutWn59x_lAgLjA2Ynk-I3t5_jNG4AdpiITO6UDFtk44C53AYYyDZz0buLSKaUrgeyZ6F_xnzfxzRyINhemEu0bPQqL33dhMbqttJX3d6bX6sR654MDnJ9C4s7fm4cFnLD74skpvfq3woVAZtJ4NDY5Mir_E6p8RAXz1WEiKX0aD3uNWL7URz7ZcI4-wnXb1Vpn8iuclTo0Dy9cHN_-LZ_gQ8NByY-6fRnmbLECy80sn5Ldxop6bxUGF_Zv0NbJLcmkLlyPUJKxI76Ss792Li2ZjivnVzLEQ315S1SRk6r6EdH_yBDXfuLvB6ZrcHV0eHnQD5oCDEHBJC0DyrWIkiQXKdu3_n6GylSlMrUShy41nBqHbEIZxo3TNpbUIH_DkDCJi6Mcmc86dIpxYb8AiQUXXHt7-cTyxDjkpcxRJXKDQERGd2G7xSHDAPe9UoUdz6aZP9OkyEsS2YXPNS7Zfe3EkbUodkE-Q-zxAW-e_bwFcahMtNtx__r-V7_DYv9ycJqdHp-dbMASQ7rjRWSUf4NOOZnZTaQrpd6qYvM_FcztCg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1NT9wwEB0VKiEubSktbFvAlTjQQ7Jrx3GcY0VZUVoQEiAh9RDZjg0rindFslXLr2ecDwSoJ85xJMdvLL_JPL8B2GYqMalTOmKJTSPuShdhKNPIyeAmLp1SuhHIHon9M35wnp53qsqqk1V6oyex_30d-8llo62cXZthrxMbHh_u4v4UEk_-4ax0wwV4iZt2JB9k6s3_FS4EspPOp7G7J6PKP7EqJ1Sw0CEmkTJc5WH_I5dPNZIPDp3xa_jVT7fVmlzF81rH5vaJk-PzvucNvOq4KPnajlmBF9a_hZVut1dkp7Ok_rIKhyf2b9T3y63JTdvAHiElU0dCR-dQfq4tqaaNAyy5wOS-viTKl6TpgkT0P3KBZwAJdYLqHZyN905396OuEUPkmaR1RLkWSZaVImcjG-o0VOYql7mVuHy54dQ4ZBXKMG6ctqmkBnkchobJXJqUyIDew6KfersOJBVccB1s5jPLM-OQnzJHlSgNgpEYPYDPPRYFBnqYlfJ2Oq-KkNvkyE8yOYC1Fpti1jpyFD2SA5CPULsfEEy0Hz9BLBoz7X7tPzz_1S1YOv42Ln5-P_rxEZYZsp6gJaP8EyzWN3O7gayl1ptNeN4BiLbvig
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sex-dependent+regulation+of+vertebrate+somatic+growth+and+aging+by+germ+cells&rft.jtitle=Science+advances&rft.au=Abe%2C+Kota&rft.au=Ino%2C+Hikaru&rft.au=Niwa%2C+Tomomi&rft.au=Semmy%2C+Daniel&rft.date=2024-06-14&rft.pub=American+Association+for+the+Advancement+of+Science&rft.eissn=2375-2548&rft.volume=10&rft.issue=24&rft_id=info:doi/10.1126%2Fsciadv.adi1621&rft_id=info%3Apmid%2F38865462&rft.externalDBID=PMC11168456
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2375-2548&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2375-2548&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2375-2548&client=summon