Incidence, mechanism and prognostic value of activated AKT in pancreas cancer

• Published in: British journal of cancer Vol. 89; no. 11; pp. 2110 - 2115
• Main Authors: Schlieman, M G, Fahy, B N, Ramsamooj, R, Beckett, L, Bold, R J
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.12.2003
• Subjects: Adenocarcinoma - enzymology; Antibodies, Monoclonal - pharmacology; Apoptosis; Breast cancer; Cancer research; Chemotherapy; Enzyme Activation; Humans; Medical prognosis; Medical research; Molecular and Cellular Pathology; Pancreatic cancer; Pancreatic Neoplasms - enzymology; Pancreatic Neoplasms - pathology; Prognosis; Protein Serine-Threonine Kinases - metabolism; Proto-Oncogene Proteins - metabolism; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2 - immunology; Receptor, ErbB-2 - metabolism; Receptor, ErbB-2 - physiology; Tumor Cells, Cultured; Tumors; Sacramento California; United States > US; California

When activated, the serine/threonine kinase AKT mediates an antiapoptotic signal implicated in chemoresistance of various cancers. The mechanism(s) of AKT activation are unknown, though overexpression of HER-2/neu has been implicated in breast cancer. Therefore, we determined the incidence of activa...