The latest techniques for inducing macrophage differentiation

• Published in: Biotechnology and bioprocess engineering Vol. 29; no. 3; pp. 440 - 450
• Main Authors: Lee, Kyungwoo, Choi, Yonghyun, Kim, Namju, Lee, Hee-Young, Choi, Jonghoon
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.06.2024; Springer Nature B.V; 한국생물공학회
• Subjects: Antigens; Apoptosis; biocompatible materials; Biomaterials; Biomedical materials; Biotechnology; Bone marrow; Cell differentiation; Chemistry; Chemistry and Materials Science; Cytokines; Differentiation (biology); Drug delivery; Drug delivery systems; drugs; Foreign bodies; Homeostasis; Immune response; Immune system; Immunomodulation; Immunosuppressive agents; Industrial and Production Engineering; Infections; Inflammation; Macrophages; medicine; Microenvironments; Pathogens; Phenotypes; Regenerative medicine; Review Paper; Stimuli; Surgical implants; Tissue engineering; Topography; Transplants & implants; Tumor necrosis factor-TNF; 생물공학; Microenvironment; Differentiation; Regenerative medicine; Macrophage
• ISSN: 1226-8372; 1976-3816
• DOI: 10.1007/s12257-024-00091-9

Macrophages play a prominent role in tissue development, homeostasis, and repair. In addition, their fundamental and well-known functions are integral to the host’s defense system, including immune responses and debris removal from apoptotic cells. These immune cells are remarkably responsive to various stimuli in the microenvironment, inducing multiple forms of differentiation with distinct phenotypes and roles. These stimuli comprise biochemical signals and physical biomaterial properties. Thus, understanding how immune cells differentiate is crucial for designing biomaterials, tissue scaffolds, implantable materials, and regenerative medicine, such as developing new drugs and immunomodulatory drug delivery systems. This review discusses about the latest techniques in inducing immune cell differentiation.