Appearance of spermatozoon after administration of mast cell blocker to a patient with azoospermia

Since a close relationship has been suggested to exist between testicular disfunction and the increased mast cells in the testis, we used a mast cell blocker for the treatment of patients with idiopathic infestility. An infertile male with idiopathic azoospermia was treated with administration of a...

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Published inHinyokika kiyo. Acta urologica Japonica Vol. 40; no. 6; p. 541
Main Authors Yamamoto, M, Hibi, H, Miyake, K
Format Journal Article
LanguageEnglish
Published Japan 01.06.1994
Subjects
Adult
Cell Count
Cell Division - drug effects
Humans
Male
Mast Cells - cytology
Oligospermia - drug therapy
Oligospermia - physiopathology
ortho-Aminobenzoates - administration & dosage
ortho-Aminobenzoates - pharmacology
Spermatogenesis - drug effects
Testis - cytology
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ISSN0018-1994

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Summary:Since a close relationship has been suggested to exist between testicular disfunction and the increased mast cells in the testis, we used a mast cell blocker for the treatment of patients with idiopathic infestility. An infertile male with idiopathic azoospermia was treated with administration of a mast cell blocker, tranilast for one year. The patient was found to have sperm within his ejaculate. However, the ultimate goal of pregnancy was not achieved by the microfertilization technique. To evaluate the possible significance of this new treatment, further basic research will be needed to clarify the relationship between mast cell proliferation and impaired testicular function.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0018-1994