Interaction between cFLIP and Itch, a ubiquitin ligase, is obstructed in Trypanosoma cruzi-infected human cells

• Published in: Microbiology and immunology Vol. 52; no. 11; p. 539
• Main Authors: Murata, Eri, Hashimoto, Muneaki, Aoki, Takashi
• Format: Journal Article
• Language: English
• Published: Australia 01.11.2008
• Subjects: Animals; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism; Chagas Disease - parasitology; Cysteine Proteinase Inhibitors - pharmacology; HeLa Cells; Humans; Immunoprecipitation; Leupeptins - pharmacology; Proteasome Inhibitors; Repressor Proteins - metabolism; Trypanosoma cruzi - parasitology; Ubiquitin-Protein Ligases - metabolism; Ubiquitination

Death receptor-mediated host cell apoptosis, a defense strategy for elimination by the immune system of parasite-infected cells, is inhibited by Trypanosoma cruzi, the causative agent of Chagas' disease. It has previously been reported by us that, in infected cells, T. cruzi upregulates and exp...