Selective inhibition of STAT3 induces apoptosis and G cell cycle arrest in ALK-positive anaplastic large cell lymphoma

• Published in: Oncogene Vol. 23; no. 32; pp. 5426 - 5434
• Main Authors: Amin, Hesham M, McDonnell, Timothy J, Ma, Yupo, Lin, Quan, Fujio, Yasushi, Kunisada, Keita, Leventaki, Vasiliki, Das, Pamela, Rassidakis, George Z, Cutler, Cathy, Medeiros, L Jeffrey, Lai, Raymond
• Format: Journal Article
• Language: English
• Published: England 15.07.2004
• Subjects: Apoptosis - genetics; Blotting, Western; DNA-Binding Proteins - antagonists & inhibitors; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; G1 Phase - genetics; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, Large B-Cell, Diffuse - genetics; Lymphoma, Large B-Cell, Diffuse - metabolism; Lymphoma, Large B-Cell, Diffuse - pathology; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases - genetics; Protein-Tyrosine Kinases - metabolism; STAT3 Transcription Factor; Trans-Activators - antagonists & inhibitors; Trans-Activators - genetics; Trans-Activators - metabolism; Tyrosine - genetics; Tyrosine - metabolism

Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) is an aberrant fusion gene product expressed in a subset of cases of anaplastic large cell lymphoma (ALCL). It has been shown that NPM-ALK binds to and activates signal transducer and activator of transcription 3 (STAT3) in vitro, and that STAT3 is...