Positive predictive value of additional synchronous breast lesions in wholebreast ultrasonography at the diagnosis of breast cancer: clinical and imaging factors

• Published in: Ultrasonography (Seoul, Korea) pp. 170 - 177
• Main Authors: 김아현, 김민정, 김은경, 박병우, 문희정
• Format: Journal Article
• Language: English
• Published: 대한초음파의학회 01.07.2014
• Subjects: 방사선과학
• ISSN: 2288-5919; 2288-5943
• DOI: 10.14366/usg.14004

Purpose: To evaluate the positive predictive value (PPV) of bilateral whole-breast ultrasonography(BWBU) for detection of synchronous breast lesions on initial diagnosis of breast cancer andevaluate factors affecting the PPV of BWBU according to varying clinicoimaging factors. Methods: A total of 75 patients who had synchronous lesions with pathologic confirmation atthe initial diagnosis of breast cancer during January 2007 and December 2007 were included. The clinical factors of the patients were evaluated. One observer retrospectively reviewed theimaging studies of the index breast cancer lesion and the synchronous lesion. The PPV foradditional biopsy was calculated for BWBU and various clinical and imaging factors affecting thePPV for BWBU were evaluated. Results: The overall PPV for additional biopsy was 25.7% (18 of 70). The PPV for synchronouslesions detected both on mammography and BWBU, and detected only on BWBU, was 76.9%(10 of 13) and 14.3% (7 of 49), respectively. There was no clinical factor affecting the PPV forBWBU. Among the imaging factors, ipsilateral location of the synchronous lesion to the indexlesion (P=0.06) showed a marginal statistically significant correlation with malignancy in thesynchronous breast lesion. A mass with calcification on mammography presentation (P<0.01),presence of calcification among the ultrasonography findings (P<0.01), and high Breast ImagingReporting and Data System final assessment (P<0.01) were imaging factors that were associatedwith malignancy in the additional synchronous lesion. Conclusion: BWBU can detect additional synchronous malignancy at the diagnosis of breastcancer with a relatively high PPV, especially when mammography findings are correlated withultrasonographic findings. KCI Citation Count: 0