Involvement of 3-methyladenine DNA glycosylases Mag1p and Mag2p in base excision repair of methyl methanesulfonate-damaged DNA in the fission yeast Schizosaccharomyces pombe

• Published in: Genes & Genetic Systems Vol. 82; no. 6; pp. 489 - 494
• Main Authors: Kyoichiro Kanamitsu, Haruna Tanihigashi, Yoshie Tanita, Saki Inatani, Shogo Ikeda
• Format: Journal Article
• Language: Japanese
• Published: The Genetics Society of Japan 01.12.2007

Schizosaccharomyces pombe has two paralogues of 3-methyladenine DNA glycosylase, Mag1p and Mag2p, which share homology with Escherichia coli AlkA. To clarify the function of these redundant enzymes in base excision repair (BER) of alkylation damage, we performed several genetic analyses. The mag1 an...