Measurement method for hydroxylated polychlorinated biphenyls in the blood of Yusho patients by liquid chromatography-electrospray tandem mass spectrometry

• Published in: Fukuoka igaku zasshi = Hukuoka acta medica Vol. 102; no. 4; p. 153
• Main Authors: Tobiishi, Kazuhiro, Todaka, Takashi, Hirakawa, Hironori, Hori, Tsuguhide, Kajiwara, Jumboku, Hirata, Teruaki, Iida, Takao, Uchi, Hiroshi, Furue, Masutaka
• Format: Journal Article
• Language: English
• Published: Japan 01.04.2011
• Subjects: Chromatography, Liquid; Food Contamination; Humans; Hydroxylation; Oryza - poisoning; Plant Oils - poisoning; Polychlorinated Biphenyls - blood; Polychlorinated Biphenyls - poisoning; Tandem Mass Spectrometry

Hydroxylated polychlorinated biphenyls (OH-PCBs) are formed as major metabolites of PCBs by cytochrome P450 enzyme-mediated oxidation. It has been reported that their total concentration in serum samples of Yusho patients ranged from 390 to 1300 pg/g. We developed a measurement method for OH-PCBs in...