Detection and characterization of Hepatitis B virus double-stranded linear DNA-derived covalently closed circular DNA in chronic hepatitis B patients

• Published in: medRxiv : the preprint server for health sciences
• Main Authors: Liu, Hsin-Ni, Kim, Elena, Wang, Zhili, Nguyen, ThiThuyTu, Shieh, Fwu-Shan, Liu, Yuanjie, Ghany, Marc G, Chung, Raymond T, Sterling, Richard K, Lin, Selena Y, Guo, Haitao, Lau, Daryl T-Y, Su, Ying-Hsiu
• Format: Journal Article
• Language: English
• Published: United States 23.01.2025

Hepatitis B virus (HBV) generates a double-stranded linear DNA (dslDNA) byproduct during replication. This dslDNA can undergo intermolecular and intramolecular nonhomologous end-joining (NHEJ) recombination, resulting in viral integration and dslDNA derived covalently closed circular DNAs (dsl-cccDN...