Bone Marrow Mesenchymal Stem Cell-Derived CD63 + Exosomes Transport Wnt3a Exteriorly and Enhance Dermal Fibroblast Proliferation, Migration, and Angiogenesis In Vitro

• Published in: Stem cells and development Vol. 26; no. 19; p. 1384
• Main Authors: McBride, Jeffrey D, Rodriguez-Menocal, Luis, Guzman, Wellington, Candanedo, Ambar, Garcia-Contreras, Marta, Badiavas, Evangelos V
• Format: Journal Article
• Language: English
• Published: United States 01.10.2017
• Subjects: Adult; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Culture Media, Conditioned - pharmacology; Endothelial Cells - cytology; Exosomes - metabolism; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - physiology; Humans; Male; Mesenchymal Stromal Cells - metabolism; Tetraspanin 30 - genetics; Tetraspanin 30 - metabolism; Wnt3A Protein - metabolism; fibroblast; exosome; Wnt3a; angiogenesis; bone marrow mesenchymal stem cell

Wnts are secreted glycoproteins that regulate stem cell self-renewal, differentiation, and cell-to-cell communication during embryonic development and in adult tissues. Bone marrow mesenchymal stem cells (BM-MSCs) have been shown to stimulate dermis repair and regeneration; however, it is unclear ho...