Attenuation of 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity by Resveratrol:A Comparative Study with Different Routes of Administration

• Published in: Biological & Pharmaceutical Bulletin Vol. 32; no. 5; pp. 876 - 881
• Main Authors: Takumi ISHIDA, Tomoki TAKEDA, Takayuki KOGA, Masahiro YAHATA, Ayako IKE, Chihiro KURAMOTO, Junko TAKETOH, Isamu HASHIGUCHI, Akifumi AKAMINE, Yuji ISHII, Hideyuki YAMADA
• Format: Journal Article
• Language: Japanese
• Published: Pharmaceutical Society of Japan 2009

The activation of aryl hydrocarbon receptor with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to be antagonized by co-treatment with resveratrol. However, such a protective effect has been suggested from studies using subcutaneous injection of this polyphenol. To evaluate the practical useful...