Atlantic Cod Trypsin-Catalyzed Peptide Synthesis with Inverse Substrates as Acyl Donor Components

• Published in: Chemical & Pharmaceutical Bulletin Vol. 58; no. 4; pp. 484 - 487
• Main Authors: Tomoyoshi FUCHISEa, Hideki KISHIMURAb, Zhi-hong YANGc, Mareshige KOJOMAa, Eiko TOYOTAa, Haruo SEKIZAKIa
• Format: Journal Article
• Language: Japanese
• Published: Pharmaceutical Society of Japan 2010

Atlantic cod trypsin-catalyzed peptide synthesis has been studied by using p-amidino- and p-guanidinophenyl esters of N-(tert-butyloxycarbonyl)amino acid as acyl donor components. The reaction temperature was optimized at 0℃. The method was shown to be successful as effectively for synthesizing the...