Novel Approach to DPI Carrier Lactose with Mechanofusion Process with Additives and Evaluation by IGC

The effect of lactose carrier surface property on the inhalation profile of dry powder inhaler (DPI) was eval-uated using a micronized drug (Compound A) by inverse gas chromatography (IGC). Mechanofusion with magnesium stearate (Mg-St) or sucrose stearate increased the line particle fraction (FPF),...

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Bibliographic Details
Published inChemical & Pharmaceutical Bulletin Vol. 54; no. 11; pp. 1508 - 1514
Main Authors Michiko KUMONa, Masahiko SUZUKIa, Akira KUSAIa, Etsuo YONEMOCHIb, Katsuhide TERADAb
Format Journal Article
LanguageJapanese
Published Pharmaceutical Society of Japan 2006
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