Effect of acidic ternary compounds on the formation of miconazole/cyclodextrin inclusion complexes by means of supercritical carbon dioxide

• Published in: Journal of pharmacy & pharmaceutical sciences Vol. 7; no. 3; pp. 378 - 388
• Main Authors: Barillaro, Valéry, Bertholet, Pascal, Henry de Hassonville, Sandrine, Ziemon, Eric, Evrard, Brigette, Delattre, Luc, Piel, Géraldine
• Format: Journal Article Web Resource
• Language: English
• Published: Canada Canadian Soc Pharmaceutical Sciences 30.11.2004
• Subjects: Carbon Dioxide - chemistry; Chemistry, Pharmaceutical; Cyclodextrins - chemistry; Human health sciences; Hydrogen-Ion Concentration; Miconazole - chemistry; Pharmacie, pharmacologie & toxicologie; Pharmacy, pharmacology & toxicology; Sciences de la santé humaine

The aim of the study is to evaluate the effect of different acidic compounds on the inclusion of miconazole (MICO) in several cyclodextrins (CDs) using supercritical carbon dioxide (SCCO(2) ) processing. Physical mixtures were processed by SCCO(2) at 30 MPa, 125 degrees C during 60 minutes in a stat...