Prognostic value of decremental responses to repetitive nerve stimulation in ALS patients

• Published in: Neurology Vol. 57; no. 5; p. 897
• Main Authors: Wang, F C, De Pasqua, V, Gérard, P, Delwaide, P J
• Format: Journal Article
• Language: English
• Published: United States 11.09.2001
• Subjects: Action Potentials - physiology; Adult; Aged; Amyotrophic Lateral Sclerosis - drug therapy; Amyotrophic Lateral Sclerosis - physiopathology; Humans; Median Nerve - physiology; Middle Aged; Muscular Atrophy - physiopathology; Neuroprotective Agents - therapeutic use; Prognosis; Prospective Studies; Riluzole - therapeutic use; Transcutaneous Electric Nerve Stimulation - methods

Decrement of the thenar compound muscle action potentials (CMAP), after repetitive nerve stimulation (RNS) of the median nerve at 3 Hz, was evaluated in patients with ALS before riluzole therapy. CMAP size as well as motor unit number and size estimates were evaluated twice before and after 1 year o...