시스플라틴 유도 신장 독성에 대한 반하사심탕 추출물의 방어효과

• Published in: 동의생리병리학회지 Vol. 32; no. 5; pp. 328 - 332
• Main Authors: 오기수(Gi Su Oh), 이수빈(Su Bin Lee), 소홍섭(Hong Seob So), 김하림(Ha Rim Kim), 이영래(Young Rae Lee), 이금산(Geum San Lee), 양세훈(Sei Hoon Yang), 임찬한(Chan Han Lim), 권강범(Kang Beom Kwon)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2018
• Subjects: 한의학; Nephrotoxicity; Banhasasim-tang; Cisplatin; Cancer
• ISSN: 1738-7698; 2288-2529; 2283-2529
• DOI: 10.15188/kjopp.2018.10.32.5.328

In this study, Banhasasim-tang extracts (BSTE) have an inhibitory effects on cisplatin-induced nephrotoxicity in mouse model. Cisplatin is the most widely used anticancer drug for treatment of various cancer. However, cisplatin treatment to cancer patients leads to many side effects such as nephrotoxicity and body weight decrease. We hypothesize that BSTE improve the cisplatin-induced side effects in mouse model. We found that BSTE administration protected tubular injury by cisplatin in mouse model. BSTE also inhibited increase of creatinine and BUN induced by cisplatin injection in serum. Collectively, our data suggest that BSTE could be a therapeutic agent for reducing kidney injury induced by cisplatin treatment in cancer patients.