시스플라틴 유도 신장 독성에 대한 반하사심탕 추출물의 방어효과

In this study, Banhasasim-tang extracts (BSTE) have an inhibitory effects on cisplatin-induced nephrotoxicity in mouse model. Cisplatin is the most widely used anticancer drug for treatment of various cancer. However, cisplatin treatment to cancer patients leads to many side effects such as nephroto...

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Published in동의생리병리학회지 Vol. 32; no. 5; pp. 328 - 332
Main Authors 오기수(Gi Su Oh), 이수빈(Su Bin Lee), 소홍섭(Hong Seob So), 김하림(Ha Rim Kim), 이영래(Young Rae Lee), 이금산(Geum San Lee), 양세훈(Sei Hoon Yang), 임찬한(Chan Han Lim), 권강범(Kang Beom Kwon)
Format Journal Article
LanguageKorean
Published 한의병리학회 2018
Subjects
한의학
Nephrotoxicity
Banhasasim-tang
Cisplatin
Cancer
Online AccessGet full text
ISSN1738-7698
2288-2529
2283-2529
DOI10.15188/kjopp.2018.10.32.5.328

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Abstract In this study, Banhasasim-tang extracts (BSTE) have an inhibitory effects on cisplatin-induced nephrotoxicity in mouse model. Cisplatin is the most widely used anticancer drug for treatment of various cancer. However, cisplatin treatment to cancer patients leads to many side effects such as nephrotoxicity and body weight decrease. We hypothesize that BSTE improve the cisplatin-induced side effects in mouse model. We found that BSTE administration protected tubular injury by cisplatin in mouse model. BSTE also inhibited increase of creatinine and BUN induced by cisplatin injection in serum. Collectively, our data suggest that BSTE could be a therapeutic agent for reducing kidney injury induced by cisplatin treatment in cancer patients.
AbstractList In this study, Banhasasim-tang extracts (BSTE) have an inhibitory effects on cisplatin-induced nephrotoxicity in mouse model. Cisplatin is the most widely used anticancer drug for treatment of various cancer. However, cisplatin treatment to cancer patients leads to many side effects such as nephrotoxicity and body weight decrease. We hypothesize that BSTE improve the cisplatin-induced side effects in mouse model. We found that BSTE administration protected tubular injury by cisplatin in mouse model. BSTE also inhibited increase of creatinine and BUN induced by cisplatin injection in serum. Collectively, our data suggest that BSTE could be a therapeutic agent for reducing kidney injury induced by cisplatin treatment in cancer patients.
In this study, Banhasasim-tang extracts (BSTE) have an inhibitory effects on cisplatin-induced nephrotoxicity in mouse model. Cisplatin is the most widely used anticancer drug for treatment of various cancer. However, cisplatin treatment to cancer patients leads to many side effects such as nephrotoxicity and body weight decrease. We hypothesize that BSTE improve the cisplatin-induced side effects in mouse model. We found that BSTE administration protected tubular injury by cisplatin in mouse model. BSTE also inhibited increase of creatinine and BUN induced by cisplatin injection in serum. Collectively, our data suggest that BSTE could be a therapeutic agent for reducing kidney injury induced by cisplatin treatment in cancer patients. KCI Citation Count: 0
Author 권강범(Kang Beom Kwon)
이금산(Geum San Lee)
소홍섭(Hong Seob So)
임찬한(Chan Han Lim)
이수빈(Su Bin Lee)
이영래(Young Rae Lee)
양세훈(Sei Hoon Yang)
오기수(Gi Su Oh)
김하림(Ha Rim Kim)
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  fullname: 김하림(Ha Rim Kim)
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  fullname: 권강범(Kang Beom Kwon)
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DocumentTitleAlternate Inhibitory Effects of Banhasasim-tang Extracts on Cisplatin-induced Nephrotoxicity in Mouse Model
DocumentTitle_FL Inhibitory Effects of Banhasasim-tang Extracts on Cisplatin-induced Nephrotoxicity in Mouse Model
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Keywords Nephrotoxicity
Banhasasim-tang
Cisplatin
Cancer
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Title 시스플라틴 유도 신장 독성에 대한 반하사심탕 추출물의 방어효과
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