함초 에탄올 추출물의 멜라닌 합성 억제를 통한 미백 효과

• Published in: 생약학회지 Vol. 46; no. 4; pp. 315 - 320
• Main Authors: 고은실(Eun Sil Ko), 강제란(Jae Ran Kang), 최미래(Mi Rae Choi), 황승미(Seung Mi Hwang), 최경민(Kyung Min Choi), 차정단(Jeong Dan Cha)
• Format: Journal Article
• Language: Korean
• Published: 한국생약학회 2015
• Subjects: 약학; Melanogenesis; Salicornia herbacea; Tyrosinase; MAPKs
• ISSN: 0253-3073; 2288-9299

This study was carried out to investigate the effect of ethanolic extract Salicornia herbacea (SHEE) on melanogenesis and mechanism. The SHEE on ${\alpha}$-melanocyte stimulating hormone (${\alpha}$-MSH) induces melanogenesis in B16F10 melanoma cells. The effect of SHEE remarkably decreased protein expression of tyrosinase and tyrosinase relate protein (TRP)-2 increased extracellular signal related kinase (ERK) on ${\alpha}$-MSH 100 nM induced melanogenesis on B16F10 melanoma cells at dose-dependent manner. It has been reported that the activation of ERK reduce melanin synthesis by down-regulating micro-phthalmia-associated transcription fator (MITF). These results sugggest that possibility of extracted korean medicinal herbs as a functional ingredient for whitening cosmetic formula.