유방암세포에서 광금전초 추출물의 암전이 억제 효과

• Published in: 동의생리병리학회지 Vol. 28; no. 5; pp. 494 - 498
• Main Authors: 황진기(Jin Ki Hwang), 안찬근(Chan Gn An), 김성철(Seong Cheol Kim), 이수호(Soo Ho Lee), 박승혁(Sueng Hyuk Park), 류도곤(Do Gon Ryu), 이금산(Guem San Lee), 이영래(Young Rae Lee), 김병숙(Byung Sook Kim), 권강범(Kang Beom Kwon)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2014
• Subjects: 한의학; Desomodii Herba; MCF-7 human breast cancer cells; matrix metalloproteinase-9
• ISSN: 1738-7698; 2288-2529; 2283-2529
• DOI: 10.15188/kjopp.2014.10.28.5.494

It is well known that Desomodii Herba (DH) has an effect to eliminate dampness, relieve jaundice and to clear away toxic material, relieve swelling in Korean Medicine. However, the effect of DH on breast cancer invasion is unknown. In this study, we investigated the inhibitory effect of DH extracts (DHE) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-9 (MMP-9) expression and cell invasion, as well as the molecular mechanisms involved in MCF-7, human breast cancer cells. DHE inhibits TPA-induced MMP-9 protein and mRNA expressions in a dose-dependent fashion. DHE also inhibited the TPA-induced transcriptional activation of nuclear factor-kappa B (NF-${\kappa}B$). These results indicate that DHE-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of NF-${\kappa}B$ pathway in MCF-7 cells.