필발 추출물의 포도당 흡수능에 대한 효과

• Published in: 동의생리병리학회지 Vol. 28; no. 1; pp. 59 - 62
• Main Authors: 김미성(Mi Seong Kim), 권강범(Kang Beom Kwon), 송제호(Je Ho Song)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2014
• Subjects: 한의학; glucose uptake; adipocytes; Fructus Piperis Longi
• ISSN: 1738-7698; 2288-2529; 2283-2529
• DOI: 10.15188/kjopp.2014.02.28.1.59

Glucose uptake plays a pivotal role in maintaining whole body glucose homeostasis in adipocytes and skeletal muscles. In the present study we have shown that Fructus Piperis Longi Extracts (FPLE) can stimulate glucose uptake in OP9 adipocytes. The increasing effects of FPLE on glucose uptake were inhibited by compound C pretreatment, which means that the glucose uptake effects by FPLE were carried out by AMP-activated protein kinase (AMPK) activation. Further studies revealed that FPLE stimulated glucose transport occurs through a mechanism involving extracellular signal-regulated kinase (ERK1/2) activation.