알츠하이머병 환자에서 해마 위축과 정신병적 증상

• Published in: Singyŏng chŏngsin ŭihak Vol. 57; no. 3; pp. 261 - 265
• Main Author: 정희정, 이영민, 박제민, 이병대, 문은수, 김수연
• Format: Journal Article
• Language: Korean
• Published: 대한신경정신의학회 31.08.2018
• Subjects: 정신과학; Alzheimer’s disease; Psychotic symptoms; Hippocampus; Medial temporal lobe
• ISSN: 1015-4817; 2289-0963
• DOI: 10.4306/jknpa.2018.57.3.261

Objectives This study examined the difference in the volume or thickness of the medial temporal lobe between Alzheimer’s disease patients with psychosis (AD+P) and those without psychosis (AD-P). Methods Overall, 31 AD+P patients and 29 AD-P patients were included from the Memory impairment clinics of Pusan National University Hospital in Korea. AD+P was diagnosed according to Jeste and Finkel’s proposed diagnostic criteria for psychosis of Alzheimer’s disease. AD-P included AD patients with no psychotic symptoms during a 5-year follow-up period. Medial temporal volume or thickness was measured by 3-tesla MRI and freesufer analysis. Analysis of variance was used to examine the difference in the volume or thickness of medial temporal lobe between AP+P and AD-P after controlling for age, gender, education years, Clinical Dementia Rating scale-Sum of Box, and total intracranial volume. Results The hippocampal volume in AD+P was smaller than that in AD-P. Conclusion These findings suggest that AD+P is associated with a reduced hippocampal volume. KCI Citation Count: 0