1-아릴옥시메틸-2,4,5-트리플루오로벤젠 유도체의 합성 및 CCL2 발현의 억제 활성

• Published in: Yaghag-hoi-ji Vol. 65; no. 5; pp. 370 - 374
• Main Authors: 김민정(Min Jung Kim), 조아영(Ahyoung Jo), 김관회(Koanhoi Kim), 곽재환(Jae-Hwan Kwak)
• Format: Journal Article
• Language: Korean
• Published: The Pharmaceutical Society Of Korea 30.10.2021; 대한약학회
• Subjects: 약학; CCL2 expression; 2; 4; 5-Trifluorobenzyloxy)benzene; 5-Trifluorobenzyloxy)naphthalene

CCL2 overexpression is associated with macrophage recruitment during immune response and poor patientprognosis in various cancers, such as prostate, breast, pancreatic, and liver cancer. For developing CCL2 inhibitors, 1-aryloxymethyl-2,4,5-trifluorobenzene analogs were designed and synthesized by c...