Low Dose Effect와 Non Monotonic Dose Responses(NMDRs) 그리고 의학적 의미 - 용량-반응관계의 새로운 패러다임을 중심으로

• Published in: 대한예방한의학회지 Vol. 20; no. 1; pp. 145 - 159
• Main Authors: 성 안젤라동민, 신지연, 이승은, 박송미, 오연지, 이선동, Sung, Angela Dongmin, Shin, Jeeyoun, Lee, Seungeun, Park, Songmi, Oh, Yeonji, Lee, Sundong
• Format: Journal Article
• Language: Korean
• Published: 대한예방한의학회 01.04.2016
• Subjects: 한의학; low dose effect; Medicine; Korean medicine; non monotonic dose responses(NMDRs); dose response
• ISSN: 1226-7066; 2713-9360

Objectives : The aim was to investigate the characteristics of low dose effect and non monotonic dose responses(NMDRs) and to predict the influence it might have on the health and medicine, traditional Korean medicine. Methods : By investigating recently published major literatures related to low dose effect and NMDRs, the definition, mechanism, major related fields, and the influence on public health and medicine has been categorized and summarized. Results : Although there are still heated debates about the definition of low dose, it implies the biological responses in environmental exposure level and the NDMDRs means the nonlinear relationship between the dose-response in the slope sign change. Also, it implies the new form of the curve showing a U, reverse U shape, and the slop sign constantly changing showing various forms. This mechanism is because the two acceptor shows opposing effects to toxic materials and the affinity is different along with the numerical value that increase and decrease being different. These characteristics generally appear in endocrine disrupters such as bisphenol A, agricultural pesticides, metal, and radiation. The research field in the public health and medical treatment is obesity, problems in metabolism, growth hormone treatment, climacteric treatment, breast cancer, intake of Korean traditional medicine for pregnancy, menopause and phytoestrogen. Conclusions : As a result of discussing implications, NMDRs is a particular effect in low dose and heated debates surround this response, research is being conducted surrounding the field of obesity, problems in metabolism, growth hormone treatment, climacteric treatment, breast cancer, intake of Korean traditional medicine for pregnancy, menopause, and phytoestrogen. More research and interest in needed as it can have a massive influence in the public health and medicine.