Atorvastatin inhibits the proliferation of MKN45-derived gastric cancer stem cells in a mevalonate pathway-independent manner

Gastric cancer stem cells (GCSCs) are a major cause of radioresistance and chemoresistance in gastric cancer (GC). Therefore, targeting GCSCs is regarded as a powerful strategy for the effective treatment of GC. Atorvastatin is a widely prescribed cholesterol-lowering drug that inhibits 3-hydroxy-3-...

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Bibliographic Details
Published inThe Korean journal of physiology & pharmacology Vol. 26; no. 5; pp. 367 - 375
Main Author 최예슬(Ye Seul Choi), 조희정(Hee Jeong Cho), 정혜진(Hye Jin Jung)
Format Journal Article
LanguageKorean
Published 대한생리학회-대한약리학회 30.09.2022
The Korean Journal of Physiology & Pharmacology Editorial Office
Subjects
Atorvastatin
Mevalonate
Cancer stem cells
Gastric cancer
Sorafenib
Online AccessGet full text
ISSN1226-4512
2093-3827

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Table of Contents:
  • INTRODUCTION METHODS RESULTS DISCUSSION FUNDING ACKNOWLEDGEMENTS CONFLICTS OF INTEREST REFERENCES