Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway

• Published in: The Korean journal of physiology & pharmacology Vol. 13; no. 3; pp. 201 - 207
• Main Authors: Baek, In-Ji, Jeon, Su-Bun, Song, Min-Ji, Yang, Enyue, Sohn, Uy-Dong, Kim, In-Kyeom
• Format: Journal Article
• Language: Korean
• Published: 대한생리학회-대한약리학회 01.01.2009; The Korean Journal of Physiology & Pharmacology Editorial Office
• Subjects: CPI-17; Rho kinase; Vasorelaxation; Flavone; RhoA; MYPT1

Our previous study demonstrated that flavone inhibits vascular contractions by decreasing the phosphorylation levelof the myosin phosphatase target subunit (MYPT1). In the present study, we hypothesized that flavone attenuates vascular contractions through the inhibition of the RhoA/Rho kinase pathw...