Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways

• Published in: The Korean journal of physiology & pharmacology Vol. 19; no. 3; pp. 219 - 228
• Main Authors: Cui, Yanji, Park, Jee-Yun, Wu, Jinji, Lee, Ji Hyung, Yang, Yoon-Sil, Kang, Moon-Seok, Jung, Sung-Cherl, Park, Joo Min, Yoo, Eun-Sook, Kim, Seong-Ho, Ahn Jo, Sangmee, Suk, Kyoungho, Eun, Su-Yong
• Format: Journal Article
• Language: Korean
• Published: 대한생리학회-대한약리학회 01.01.2015; The Korean Journal of Physiology & Pharmacology Editorial Office
• Subjects: Neuron-microglia co-culture; Akt; gp91 phox; Dieckol; Microglia; gp91^{phox}

Excessive microglial activation and subsequent neuroinflammation lead to synaptic loss and dysfunction as well as neuronal cell death, which are involved in the pathogenesis and progression of several neurodegenerative diseases. Thus, the regulation of microglial activation has been evaluated as eff...