저도이형성증이 진단된 한국인 염증성장질환에서 진행성 신생물의 발생빈도 및 위험인자

Background/Aims: Studies on the clinical outcomes after detecting low-grade dysplasia (LGD) in patients with inflammatory bowel disease (IBD) are insufficient. This study evaluated the clinical features, frequency, and risk factors for advanced neoplasia in patients with IBD after an LGD diagnosis....

Full description

Saved in:
Bibliographic Details
Published inThe Korean journal of gastroenterology Vol. 85; no. 1; pp. 34 - 43
Main Authors 박용은, Yong Eun Park, 김경옥, Kyeong Ok Kim, 김동현, Dong Hyun Kim, 박수경, Soo-kyung Park, 이유진, Yoo Jin Lee, 이창균, Chang Kyun Lee
Format Journal Article
LanguageEnglish
Korean
Published 대한소화기학회 31.01.2025
Subjects
Colorectal neoplasm
Inflammatory bowel disease
Risk factors
내과학
Online AccessGet full text
ISSN1598-9992
2233-6869

Cover

Abstract Background/Aims: Studies on the clinical outcomes after detecting low-grade dysplasia (LGD) in patients with inflammatory bowel disease (IBD) are insufficient. This study evaluated the clinical features, frequency, and risk factors for advanced neoplasia in patients with IBD after an LGD diagnosis. Methods: The medical records of 166 patients with IBD from six university hospitals in Korea from 2010 to 2019 were reviewed retrospectively. LGD was diagnosed in all patients during surveillance. The frequency and risk factors for advanced neoplasia were evaluated, and the clinical features of patients with and without advanced neoplasia were compared. Results: Advanced neoplasia developed in 12 patients (six with large LGD, three with tubulovillous adenoma, and three with high-grade dysplasia), and all cases developed from UC. Patients with advanced neoplasia had significantly higher Mayo scores, and colitis-associated dysplasia was more common than sporadic lesions (83.3% vs. 29.9%; p<0.001). Multivariate analysis showed that colitis-associated LGD significantly increased the risk of developing advanced neoplasia (odds ratio [OR], 10.516; 95% confidence interval [CI], 2.064-53.577). Among patients with colitis-associated lesions, a significant risk factor for advanced neoplasia was a prior history of LGD (OR, 9.429; 95% CI, 1.330-66.863). Conclusions: Advanced neoplasia developed in 7.2% of patients with IBD and LGD. Most advanced neoplasms developed from colitis- associated lesions, and the risk was higher in patients with a history of LGD before index colonoscopy. (Korean J Gastroenterol 2025;85:34-43)
AbstractList Background/Aims: Studies on the clinical outcomes after detecting low-grade dysplasia (LGD) in patients with inflammatory bowel disease (IBD) are insufficient. This study evaluated the clinical features, frequency, and risk factors for advanced neoplasia in patients with IBD after an LGD diagnosis. Methods: The medical records of 166 patients with IBD from six university hospitals in Korea from 2010 to 2019 were reviewed retrospectively. LGD was diagnosed in all patients during surveillance. The frequency and risk factors for advanced neoplasia were evaluated, and the clinical features of patients with and without advanced neoplasia were compared. Results: Advanced neoplasia developed in 12 patients (six with large LGD, three with tubulovillous adenoma, and three with high-grade dysplasia), and all cases developed from UC. Patients with advanced neoplasia had significantly higher Mayo scores, and colitis-associated dysplasia was more common than sporadic lesions (83.3% vs. 29.9%; p<0.001). Multivariate analysis showed that colitis-associated LGD significantly increased the risk of developing advanced neoplasia (odds ratio [OR], 10.516; 95% confidence interval [CI], 2.064-53.577). Among patients with colitis-associated lesions, a significant risk factor for advanced neoplasia was a prior history of LGD (OR, 9.429; 95% CI, 1.330-66.863). Conclusions: Advanced neoplasia developed in 7.2% of patients with IBD and LGD. Most advanced neoplasms developed from colitis- associated lesions, and the risk was higher in patients with a history of LGD before index colonoscopy. (Korean J Gastroenterol 2025;85:34-43)
Background/Aims: Studies on the clinical outcomes after detecting low-grade dysplasia (LGD) in patients with inflammatory bowel disease (IBD) are insufficient. This study evaluated the clinical features, frequency, and risk factors for advanced neoplasia in patients with IBD after an LGD diagnosis. Methods: The medical records of 166 patients with IBD from six university hospitals in Korea from 2010 to 2019 were reviewed retrospectively. LGD was diagnosed in all patients during surveillance. The frequency and risk factors for advanced neoplasia were evaluated, and the clinical features of patients with and without advanced neoplasia were compared. Results: Advanced neoplasia developed in 12 patients (six with large LGD, three with tubulovillous adenoma, and three with high-grade dysplasia), and all cases developed from UC. Patients with advanced neoplasia had significantly higher Mayo scores, and colitis-associated dysplasia was more common than sporadic lesions (83.3% vs. 29.9%; p<0.001). Multivariate analysis showed that colitis-associated LGD significantly increased the risk of developing advanced neoplasia (odds ratio [OR], 10.516; 95% confidence interval [CI], 2.064–53.577). Among patients with colitis-associated lesions, a significant risk factor for advanced neoplasia was a prior history of LGD (OR, 9.429; 95% CI, 1.330–66.863). Conclusions: Advanced neoplasia developed in 7.2% of patients with IBD and LGD. Most advanced neoplasms developed from colitis- associated lesions, and the risk was higher in patients with a history of LGD before index colonoscopy. KCI Citation Count: 0
Author 박수경
이창균
박용은
Yong Eun Park
Yoo Jin Lee
Dong Hyun Kim
Chang Kyun Lee
김경옥
Soo-kyung Park
Kyeong Ok Kim
이유진
김동현
Author_xml – sequence: 1
  fullname: 박용은
– sequence: 2
  fullname: Yong Eun Park
– sequence: 3
  fullname: 김경옥
– sequence: 4
  fullname: Kyeong Ok Kim
– sequence: 5
  fullname: 김동현
– sequence: 6
  fullname: Dong Hyun Kim
– sequence: 7
  fullname: 박수경
– sequence: 8
  fullname: Soo-kyung Park
– sequence: 9
  fullname: 이유진
– sequence: 10
  fullname: Yoo Jin Lee
– sequence: 11
  fullname: 이창균
– sequence: 12
  fullname: Chang Kyun Lee
BackLink https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART003169055$$DAccess content in National Research Foundation of Korea (NRF)
BookMark eNotj81Kw0AUhQdRsNY-gZushUAmyUxnlqX4UygI0n2YJhkJ0VaShbgTzKLSRbupjZCUbrQuFBQUFPpE5uYdnFpX5557Pg6cHbTZ6_f8DVQxTcvSKaN8E1Uw4UznnJvbqBbHQddQD0yxgSvoCuY3xSiB_KNMJ5C8w1Oubg0WSTF8LsaZVk6yn89XyL80mC5XqWJmj7AYlA8pTMeQZCu4vL9TgQbDOdzmxcsS8lQr3rKV-R6ofmVGGmRJOU1VFczGu2hLivPYr_1rFXUODzrNY719ctRqNtp6SIitS8o87rmEmVJytchX1rKZNBgzbMt1PcO0u4QJX3a5wMzzGfUFFYQyLOu-5VlVtL-u7UXSCd3A6YvgT8_6Thg5jdNOy8EGrdM6sRW8t4bDII6dyyi4ENG1Y2OCKTetX6e2jDg
ContentType Journal Article
DBID HZB
Q5X
ACYCR
DatabaseName Korea Information Science Society (KISS)
Korean Studies Information Service System (KISS) B-Type
Korean Citation Index
DatabaseTitleList

DeliveryMethod fulltext_linktorsrc
DocumentTitleAlternate 저도이형성증이 진단된 한국인 염증성장질환에서 진행성 신생물의 발생빈도 및 위험인자
Frequency and Risk Factors of Advanced Neoplasia in Korean Inflammatory Bowel Disease Patients with Low-grade Dysplasia
EISSN 2233-6869
EndPage 43
ExternalDocumentID oai_kci_go_kr_ARTI_10676754
4151692
GroupedDBID 5-W
8JR
8XY
9ZL
ADBBV
ALMA_UNASSIGNED_HOLDINGS
BCNDV
EBD
EF.
EMOBN
F5P
GROUPED_DOAJ
HZB
OK1
Q5X
SV3
ACYCR
ID FETCH-LOGICAL-k554-f68d9dc582ff9223e8d9348f088043ccd024b58aefb9a18de86ea6a5681f7e3d3
ISSN 1598-9992
IngestDate Sun Jan 26 10:32:43 EST 2025
Sat Apr 26 02:22:43 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
Korean
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-k554-f68d9dc582ff9223e8d9348f088043ccd024b58aefb9a18de86ea6a5681f7e3d3
Notes Korean Society of Gastroenterology
PageCount 10
ParticipantIDs nrf_kci_oai_kci_go_kr_ARTI_10676754
kiss_primary_4151692
PublicationCentury 2000
PublicationDate 20250131
PublicationDateYYYYMMDD 2025-01-31
PublicationDate_xml – month: 01
  year: 2025
  text: 20250131
  day: 31
PublicationDecade 2020
PublicationTitle The Korean journal of gastroenterology
PublicationTitleAlternate 대한소화기학회지
PublicationYear 2025
Publisher 대한소화기학회
Publisher_xml – name: 대한소화기학회
SSID ssib015916101
ssib003110202
ssib059854591
ssj0064443
Score 2.3262153
Snippet Background/Aims: Studies on the clinical outcomes after detecting low-grade dysplasia (LGD) in patients with inflammatory bowel disease (IBD) are insufficient....
SourceID nrf
kiss
SourceType Open Website
Publisher
StartPage 34
SubjectTerms Colorectal neoplasm
Inflammatory bowel disease
Risk factors
내과학
Title 저도이형성증이 진단된 한국인 염증성장질환에서 진행성 신생물의 발생빈도 및 위험인자
URI https://kiss.kstudy.com/ExternalLink/Ar?key=4151692
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART003169055
Volume 85
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX 대한소화기학회지, 2025, 85(1), , pp.34-43
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NaxNBFB_anryIUsX6xYLOqWzZ7MfszHF3m1IVPVXoLexmZ4sEEtmmCB5EMIdKD82lNkJSetF6UFBQUOjRv8ZM_gffzOymiQSpXpaZN2_ee_NeNvOb3Z03CN1NUhbLHdZmkvDMdGHCNRPXT00O4MBOfAJ_yyrb5yOy_ti9v-ltzs3_nPhqaaedrNSfz9xX8j9RBRrEVe6S_YfIjoUCAcoQX7hChOF6rhjjaoQDS36sUA0xXcPUlRS2ikMorGJGMfMkBehhRTET2VryLCuSr7pB_xAHVBaYhVm0rAR4UMLVAIceDsb9qOrHfBxGUzLHWlgVB14pmypBTBqje4F4zayUjA0AJoIpGwtSbdImze4oJVCNCrVMjm9ZkkJLWTnBFDKlt_BJyUTXtOFRqc8vjZKDKgzXp4qWcF3eRA9aefm2okDuW_F2O2_JZKb51EuJ0hg1dhbggBXSqXXGEijrLFWwcai9SsFhM1jUAMB3OpbUnakIRiqHUYibfIpjyw8my-lP3ndKYqREj4MLVSKJRZRcJYlK8QWPVh8Az-QExmACY_p8wRWuaIAAHZNQfSROMVEVT5A15NGJsqaTkf8BEqbSkTfqT2pbrVojr8Gi615NZiGEdac7j-adils-1tBoCOC23uRS2gXQB1ZG2wDlmnk2AeU2LqGLxRrMCPQNdRnN8eYieiaOXw73O2LwddQ7EJ0v4v0AyoY46Qz3Pgy7fWN00P_17ZMYfDfE4alsBZ6jd-Jkd_S2Jw67otOXzKM3r6HBEHvH4tVg-PFUDHrG8HNfVn7sgnyo7Bui3xkd9kCUOOpeQRtr1Y1o3SxOJTEbAL3NjNCUpXWP2lnGwLMcqo5LM5itLdep11MAvYlHY54lLK7QlFPCYxLLPH-Zz53UuYoWmq0mv4YMm6U2odxzYsDxjPlxQhJCqBfzJAOcbi2hRemq2lOdd6YGWLtCmL2E7oDrVBD-Eozr5-K6gS6c_RpvooV2vsNvAcpuJ7dVGOH68EX1Nz9SvS8
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%EC%A0%80%EB%8F%84%EC%9D%B4%ED%98%95%EC%84%B1%EC%A6%9D%EC%9D%B4+%EC%A7%84%EB%8B%A8%EB%90%9C+%ED%95%9C%EA%B5%AD%EC%9D%B8+%EC%97%BC%EC%A6%9D%EC%84%B1%EC%9E%A5%EC%A7%88%ED%99%98%EC%97%90%EC%84%9C+%EC%A7%84%ED%96%89%EC%84%B1+%EC%8B%A0%EC%83%9D%EB%AC%BC%EC%9D%98+%EB%B0%9C%EC%83%9D%EB%B9%88%EB%8F%84+%EB%B0%8F+%EC%9C%84%ED%97%98%EC%9D%B8%EC%9E%90&rft.jtitle=The+Korean+journal+of+gastroenterology&rft.au=%EB%B0%95%EC%9A%A9%EC%9D%80&rft.au=%EA%B9%80%EA%B2%BD%EC%98%A5&rft.au=%EA%B9%80%EB%8F%99%ED%98%84&rft.au=%EB%B0%95%EC%88%98%EA%B2%BD&rft.date=2025-01-31&rft.pub=%EB%8C%80%ED%95%9C%EC%86%8C%ED%99%94%EA%B8%B0%ED%95%99%ED%9A%8C&rft.issn=1598-9992&rft.eissn=2233-6869&rft.spage=34&rft.epage=43&rft.externalDBID=n%2Fa&rft.externalDocID=oai_kci_go_kr_ARTI_10676754
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1598-9992&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1598-9992&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1598-9992&client=summon