토끼에서 EPO(Erythropoietin)의 안점막자극성 및 피부자극성시험

• Published in: 한국독성학회지 Vol. 13; no. 1; pp. 149 - 152
• Main Authors: 강병철, 남정석, 제정환, 이석만, 양재만, 이학모, 박재학, 송동호, 유선희
• Format: Journal Article
• Language: Korean
• Published: 1997
• Subjects: Erythropoietin; Skin irritation; Ocular irritation
• ISSN: 0258-2368

This test was performed to evaluate the ocular and skin irritation of EPO (Erythropoietin). The results as follows: 1. Ocular irritation test There were no observed clinical signs, body weght changes by EPO during experimental period. The acute ocular irritation index(A.O.I.), mean ocular irritation index(M.O.I.) and Day-7 individual ocular irritation index(I.O.I.) of EPO at dose of 1000U and 10, 000U were 0, respectively. Therefore we evaluated that EPO was non-toxic to eyes. 2. Skin irritation test There were no observed clinical signs, body weght changes and gross pathologic findings by EPO during experimental period. There were no observed erythema, eschar formation and edema formation on intact and abraded skin treated by EPO. The primary irritation index(P.I.I.) of EPO at dose of 1000U and 10, 000U were 0, respectively and were evaluated none irritating product about skin irritation.