Inhibition of Wnt Signaling by Silymarin in Human Colorectal Cancer Cells

• Published in: Biomolecules & therapeutics Vol. 24; no. 4; pp. 380 - 386
• Main Authors: Eo, Hyun Ji, Park, Gwang Hun, Jeong, Jin Boo
• Format: Journal Article
• Language: Korean
• Published: 한국응용약물학회 01.07.2016
• Subjects: Cancer chemoprevention; Human colorectal cancer; Silymarin; Wnt signaling; Cancer chemoprevention; Human colorectal cancer; Wnt signaling; Silymarin

Silymarin from milk thistle (Silybum marianum) has been reported to show an anti-cancer activity. In previous study, we reported that silymarin induces cyclin D1 proteasomal degradation through NF-κB-mediated threonine-286 phosphorylation. However, mechanism for the inhibition of Wnt signaling by si...