Neurobiological Functions of the Period Circadian Clock 2 Gene, Per2

Most organisms have adapted to a circadian rhythm that follows a roughly 24-hour cycle, which is modulated by both internal (clock-related genes) and external (environment) factors. In such organisms, the central nervous system (CNS) is influenced by the circadian rhythm of individual cells. Further...

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Bibliographic Details
Published inBiomolecules & therapeutics Vol. 26; no. 4; pp. 358 - 367
Main Authors Kim, Mikyung, Pena, June Bryan de la, Cheong, Jae Hoon, Kim, Hee Jin
Format Journal Article
LanguageKorean
Published 한국응용약물학회 01.07.2018
Subjects
Addiction
Circadian rhythm
Depression
Neurotransmitter
Per2 gene
Sleep
Neurotransmitter
Depression
Sleep
Circadian rhythm
Addiction
Per2 gene
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Summary:Most organisms have adapted to a circadian rhythm that follows a roughly 24-hour cycle, which is modulated by both internal (clock-related genes) and external (environment) factors. In such organisms, the central nervous system (CNS) is influenced by the circadian rhythm of individual cells. Furthermore, the period circadian clock 2 (Per2) gene is an important component of the circadian clock, which modulates the circadian rhythm. Per2 is mainly expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as other brain areas, including the midbrain and forebrain. This indicates that Per2 may affect various neurobiological activities such as sleeping, depression, and addiction. In this review, we focus on the neurobiological functions of Per2, which could help to better understand its roles in the CNS.
Bibliography:The Korean Society of Applied Pharmacology
KISTI1.1003/JNL.JAKO201819063370806
ISSN:1976-9148
2005-4483