Tau mis-splicing in the pathogenesis of neurodegenerative disorders

• Published in: BMB reports Vol. 49; no. 8; pp. 405 - 413
• Main Authors: Park, Sun Ah, Ahn, Sang Il, Gallo, Jean-Marc
• Format: Journal Article
• Language: Korean
• Published: 생화학분자생물학회 31.08.2016
• Subjects: Isoform; Mechanism; Splicing; Tau; Tauopathy; Isoform; Tau; Splicing; Tauopathy; Mechanism

Tau proteins, which stabilize the structure and regulate the dynamics of microtubules, also play important roles in axonal transport and signal transduction. Tau proteins are missorted, aggregated, and found as tau inclusions under many pathological conditions associated with neurodegenerative disor...