마황(麻黃)의 기도과민반응의 효과

• Published in: 大韓本草學會誌 Vol. 20; no. 4; pp. 69 - 76
• Main Authors: 이성철, Seong Cheol Lee, 박성주, Sung Joo Park, 서상완, Sang Wan Seo, 황상욱, Sang Wook Hwang, 김영우, Yong Woo Kim, 송달수, Dal Soo Song, 채영석, Younh Seok Chae, 신민교, Min Kyo Shin, 송호준, Ho Joon Song
• Format: Journal Article
• Language: Korean
• Published: 대한본초학회 30.12.2005
• Subjects: AHR; airway hyper reactivity; BALF; bronchoaveloar Lavage fluid; HE; Herba Ephedrae; OVA; ovalbumin; bronchoaveloar lavage fluid(BALF); Herba Ephedrae(HE); airway hyper reactivity(AHR); ovalbumin (OVA)
• ISSN: 1229-1765

Objectives : HERBA EPHEDRAE (HE) has been used cough and asthma for long time in korea. In the present study, we examined the effect HE on the ovalbumin (OVA)-induced airway hyper-reactivity (AHR). Methods : To examine the effect of HE on AHR, mice were sensitized with 100 mg of OVA and 1mg of alum intraperitoneally on day 0 and 14. On day 28, mice were challenged on 3 consecutive days with 3% OVA and AHR was assessed 24 h after the last challenge. To examine severity of airway hyper-reactivity, we examined eosinophil population and cytokine production in bronchoaveloar lavage fluid(BALF) and stained with hematoxylin and eosin in lung. Results : HE potently inhibited the development of airway hyper-reactivity and also reduced the number of eosinophil during OVA-induced airway hyper-reactivity. HE also inhibited cytokines production such as IL-4, IL-5, IL-13 in BALF. Furthermore, HE inhibited proliferation of eosinophil in a dose dependent manner. Conclusions : These results suggest that HE may be beneficial oriental medicine for AHR.