Pituitary gland development: an update

• Published in: Endocrine development Vol. 23; p. 1
• Main Authors: Bancalari, Rodrigo E, Gregory, Louise C, McCabe, Mark J, Dattani, Mehul T
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.2012
• Subjects: Abnormalities, Multiple - embryology; Abnormalities, Multiple - etiology; Abnormalities, Multiple - genetics; Animals; Endocrinology - methods; Endocrinology - trends; Humans; Hypopituitarism - complications; Hypopituitarism - congenital; Hypopituitarism - embryology; Hypopituitarism - genetics; Models, Biological; Organogenesis - genetics; Organogenesis - physiology; Pituitary Gland - anatomy & histology; Pituitary Gland - embryology; Pituitary Gland - growth & development; Pituitary Gland - physiology

The embryonic development of the pituitary gland involves a complex and highly spatio-temporally regulated network of integrating signalling molecules and transcription factors. Genetic mutations in any of these factors can lead to congenital hypopituitarism in association with a wide spectrum of cr...