Advances in Cross-Coupling Reactions

• Format: eBook
• Language: English
• Published: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: 3′-bipyrrole; 5-aryl pyrrole-2-carboxylates; acylation; Al2O3; allosteric modulators; arenes; borylated aryl alkynes; borylation; C-C bond forming reactions; C-H activation; C-H functionalization; C-Heteroatom bond forming reactions; catalysis in water; clinical candidate; cross coupling; cross-coupling reactions; cyclopeptides; C–C cross-coupling; C–H borylation; dearomatization; dimerization and trimerization of indoles; DNA-encoded libraries; DSSC; electrophilic haloacetylenes; ethynylpyrroles; furans; Heck reaction; heteroarenes; heteroaryl substituted pyrroles; indigo dyes; indolin-3-ones; intramolecular cyclization; iridium-catalyzed; M(CO)3 tripods; medium-sized heterocycles; methoxycarbonylation; molecular brakes and gears; n/a; NH-Free; one-pot reaction; palladium; profene; PROTAC; pyrazoles; pyrroles; Reference, Information and Interdisciplinary subjects; Research and information: general; restricted rotations; Sonogashira cross-coupling; spectroscopy; styrene; sulfonated salan; Suzuki coupling; Suzuki–Miyaura reaction; synthesis; thiophenes; transition-metal catalysis; V-T NMR; X-ray
• DOI: 10.3390/books978-3-03943-568-5
• ISBN: 9783039435678; 303943568X; 3039435671; 9783039435685

In this Special Issue, recent advances in cross-coupling reactions are presented in the form of original research articles, reviews, and short communications. These contributions cover different topics in this area, including novel coupling reactions, reaction conditions, synthetic alternatives, metal ligands, and applications for new pharmaceutical compounds and organic materials. In particular, the reviews deal with methodologies such as the synthesis of diarylketones through palladium catalysis and the most relevant examples of Suzuki–Miyaura and Buchwald–Hartwig coupling reactions in the synthesis of bioactive compounds. The synthetic utility of cross-coupling reactions for the synthesis of medium-size rings and the utility of Stille and Suzuki coupling reactions for the synthesis of new molecular machines based on sterically hindered anthracenyl trypticenyl units are also summarized. The original research articles present the synthesis of 2-alkynylpyrrols by inverse Sonogashira coupling and the synthesis of indoles under oxidative dearomative cross-dehydrogenative conditions. The efficient combination of iridium-catalyzed C–H borylation of aryl halides with the Sonogashira coupling and a sequential iridium-catalyzed borylation of NH-free pyrroles followed by a Suzuki–Miyaura reaction are included. The synthesis of aryl propionic acids, a common structural motif in medicinal chemistry, and the synthesis of new organic dyes are also covered.