Pharmaceutical Manufacturing: The Role of Multivariate Analysis in Design Space, Control Strategy, Process Understanding, Troubleshooting, and Optimization

• Published in: Chemical Engineering in the Pharmaceutical Industry p. 1
• Main Author: Kourti, Theodora
• Format: Book Chapter
• Language: English
• Published: Hoboken, NJ, USA John Wiley & Sons 2011; John Wiley & Sons, Inc
• Subjects: Chemistry & Chemical Engineering; General References; latent variables, exploiting characteristics of process databases ‐ measurements on a large number of variables; multivariate statistical process control; pharmaceutical manufacturing ‐ role of multivariate analysis in design space, control strategy, process understanding, troubleshooting and optimization; Pharmaceuticals; Pharmaceuticals, Cosmetics & Toiletries

This chapter contains sections titled: Introduction The Nature of Process and Quality Data Latent Variable Methods for Twoway Matrices Multivariate Statistical Process Control Batch Process Monitoring Multistage Operations: Multiblock Analysis Process Control to Achieve Desired Product Quality Other...

Table of Contents:

• 44.1 Introduction 44.2 The Nature of Process and Quality Data 44.3 Latent Variable Methods for Two Way Matrices 44.4 Multivariate Statistical Process Control 44.5 Batch Process Monitoring 44.6 Multistage Operations: Multiblock Analysis 44.7 Process Control to Achieve Desired Product Quality 44.8 Other Applications of Latent Variable Methods 44.9 Quality by Design 44.10 Future Directions Acknowledgment References